The Simpsons
S11E7: Eight Misbehavin'
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How did we get eight?
Apu, I must confess.
When we were having trouble conceiving,
I took fertility drugs.
I, too, am afraid...
I'm guilty of monkeying with nature.
I slipped fertility drugs into your breakfast Squishy.
Mmm, mmm. Well, that would only account for quintuplets.