Family Guy
S9E1: And Then There Were Fewer
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PETER: Yes, he did.
Says here he talked Muriel into selling him OxyContin for him and his 19-year-old girlfriend. This went on for weeks.
But then she started to have misgivings and threatened to cut him off.
But he wouldn't let her.
He threatened to blackmail her by turning her in to the Feds.
Sounds like a pretty good motive to me.